Model parameter clustering
Clustering of model parameters based on similarity of their impact on model variables.
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Methods & software
Tools, code and data for quantitative studies of cellular signaling.
Python · Jupyter
Berg–Purcell information capacity
Python scripts and Jupyter notebooks reproducing the analytical figures for the clock-limited information capacity preprint.
sysbiosig/berg-purcell-information-capacityPython
Capacity of canonical models
Python scripts for information capacity in canonical signaling models, biochemical cascades and cell populations.
sysbiosig/Capacity-of-Canonical-ModelsR package
FRA
Fractional Response Analysis: an R package for analysing heterogeneous single-cell responses.
sysbiosig/FRAR · MATLAB
Information-theoretic signaling framework
R and MATLAB code accompanying the 2018 Nature Communications study of pleiotropic and noisy biochemical signaling.
sysbiosig/Jetka_et_al_Nature_communications_2018R · Data
Phenotypic variability
Datasets and R scripts for channel-capacity calculations and figures from the 2022 Science Signaling study.
sysbiosig/phenotypic_variabilityR package
SLEMI
An R package for estimating mutual information and channel capacity from multivariate single-cell responses.
sysbiosig/SLEMIEarlier tools & resources
StochDecomp
Matlab package for variance decomposition of stochastic chemical kinetics models into contributions from individual reactions.
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Matlab package for sensitivity analysis and Fisher information computation for stochastic models of chemical kinetics.
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